Category: Prions.RIP

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Quercetin Disaggregates Prion Fibrils and Decreases Fibril-Induced Cytotoxicity and Oxidative Stress
Quercetin Disaggregates Prion Fibrils and Decreases Fibril-Induced Cytotoxicity and Oxidative Stress
Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases caus...

The Potential of Serratiopetidase and Lumbrokinase for the Degradation of Prion Peptide 106-126 - an In Vitro and In Silico Perspective - PubMed
The Potential of Serratiopetidase and Lumbrokinase for the Degradation of Prion Peptide 106-126 - an In Vitro and In Silico Perspective - PubMed
Finally, the toxicity of the disintegrated amyloids was assessed using PC12 cell lines whi...

Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein - PubMed
Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein - PubMed
Neurodegenerative protein misfolding diseases, including prionopathies, share the common f...

Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease - PubMed
Induced dural lymphangiogenesis facilities soluble amyloid-beta clearance from brain in a transgenic mouse model of Alzheimer's disease - PubMed
Impaired amyloid-β clearance from the brain is a core pathological event in Alzheimer's di...

https://www.researchgate.net/publication/328726622_Artemisinin_B_Improves_Learning_and_Memory_Impairment_in_AD_Dementia_Mice_by_Suppressing_Neuroinflammation

Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction - PubMed
Lactoferrin protects against prion protein-induced cell death in neuronal cells by preventing mitochondrial dysfunction - PubMed
Prion disorder-related neurodegenerative diseases are characterized by the accumulation of...

Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD - PubMed
Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD - PubMed
This team of authors report that a nanoformulation of pomegranade seed oil, containing hig...

Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid
Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid
Author Summary Many serious diseases have been linked to pathogenic states of various prot...

Multiple mechanisms of age-dependent accumulation of amyloid beta protein in rat brain: Prevention by dietary supplementation with N-acetylcysteine, α-lipoic acid and α-tocopherol - PubMed
Multiple mechanisms of age-dependent accumulation of amyloid beta protein in rat brain: Prevention by dietary supplementation with N-acetylcysteine, α-lipoic acid and α-tocopherol - PubMed
The aged brain may be used as a tool to investigate altered metabolism of amyloid beta pro...

Intracellular re-routing of prion protein prevents propagation of PrPSc and delays onset of prion disease
Intracellular re-routing of prion protein prevents propagation of PrPSc and delays onset of prion disease
Prion diseases are fatal and transmissible neurodegenerative disorders linked to an aberra...

Vitamin D2 interacts with Human PrPc (90–231) and breaks PrPc oligomerization in vitro
Vitamin D2 interacts with Human PrPc (90–231) and breaks PrPc oligomerization in vitro
PrP[sc] , the pathogenic isoform of PrP[c] , can convert PrP[c] into PrP[sc] through direc...

Mefloquine, an Antimalaria Drug with Antiprion Activity In Vitro, Lacks Activity In Vivo
Mefloquine, an Antimalaria Drug with Antiprion Activity In Vitro, Lacks Activity In Vivo
In view of the effectiveness of antimalaria drugs inhibiting abnormal protease-resistant p...

The curious antiprion activity of antimalarial quinolines
A series of antimalarial quinoline compounds potently inhibit prion accumulation in cell c...

https://www.sciencedaily.com/releases/2006/10/061030120759.htm


Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment
Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment
The mechanisms of neuronal death in protein misfolding neurodegenerative diseases such as ...

Degradation of the disease-associated prion protein by a serine protease from lichens - PubMed
Degradation of the disease-associated prion protein by a serine protease from lichens - PubMed
The disease-associated prion protein (PrP(TSE)), the probable etiological agent of the tra...

https://www.nature.com/articles/nature.2016.20509

Normal prions as a new target of cobalamin (vitamin B12) in rat central nervous system - PubMed
Normal prions as a new target of cobalamin (vitamin B12) in rat central nervous system - PubMed
The pathogenesis of cobalamin (Cbl)-deficient (Cbl-D) neuropathy and the role of normal pr...

Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-κB and AP-1 Activation - PubMed
Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-κB and AP-1 Activation - PubMed
Over activation of microglia results in the production of proinflammatory agents that have...

Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity - PubMed
Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity - PubMed
Our previous study revealed that resveratrol blocks prion protein peptide PrP(106-126)-ind...

Information

https://www.francesoir.fr/opinions-tribunes/que-sont-les-prions-partie-ii-covid#.YVQOdvzqw1U.twitter

Microglia Form Networks That Engulf and Clear Pathogenic α-Synuclein
Microglia Form Networks That Engulf and Clear Pathogenic α-Synuclein
When microglia are exposed to α-synuclein, they establish a network of intercellular conne...

Woman Dies of Rare Brain Disease Within 3 Months of Second Pfizer Shot, Doctor Says Vaccine Could Be Responsible
Woman Dies of Rare Brain Disease Within 3 Months of Second Pfizer Shot, Doctor Says Vaccine Could Be Responsible
In an exclusive interview with The Defender, Gianni Cohen said her mother, Cheryl Cohen, d...

https://www.alz.org/aaic/releases_2021/covid-19-cognitive-impact.asp

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New study finds COVID-19 can cause changes in brain that mimic Alzheimer's disease
New study finds COVID-19 can cause changes in brain that mimic Alzheimer's disease
A new study shows that COVID-19 symptoms that some describe as "brain fog" may be caused b...

SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation
SARS-CoV-2 nucleoprotein can trigger α-synuclein amyloid fibril formation
A new study, released as a preprint on the bioRxiv* server, casts some light on the pathog...
Amyloidosis - Symptoms and causes
Amyloidosis - Symptoms and causes
http://www.cnrs.fr/en/node/5908

SARS-CoV-2 Prion-Like Domains in Spike Proteins Enable Higher Affinity to ACE2
SARS-CoV-2 Prion-Like Domains in Spike Proteins Enable Higher Affinity to ACE2
Currently, the world is struggling with the coronavirus disease 2019 (COVID-19) pandemic, ...
SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration
SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration
The post-infection of COVID-19 includes a myriad of neurologic symptoms including neurodeg...
Articles Inpress Articles | Journal of Medical - Clinical Research & Reviews | SciVision Publishers
Articles Inpress Articles, Journal of Medical - Clinical Research & Reviews, SciVision Pub...

COVID-19 RNA Based Vaccines and the Risk of Prion Disease | Principia Scientific Intl.
COVID-19 RNA Based Vaccines and the Risk of Prion Disease | Principia Scientific Intl.
Vaccines have been found to cause a host of chronic, late developing adverse events. Some ...
SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration
SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration
The post-infection of COVID-19 includes a myriad of neurologic symptoms including neurodeg...
Prions: Beyond a Single Protein
Prions: Beyond a Single Protein
Since the term protein was first coined in 1838 and protein was discovered to be the essen...
CBC News/Radio-Canada distributing 50,000 postcards to learn more about mystery illness
Mystery disease takes life of a North Pole leader
Mystery disease takes life of a North Pole leader
McCoy died this summer, two weeks after doctors diagnosed him with Creutzfeldt-Jakob Disea...
https://www.cdc.gov/cpr/zombie/index.htm


There Is No Safe Dose of Prions
There Is No Safe Dose of Prions
Understanding the circumstances under which exposure to transmissible spongiform encephalo...
https://journals.lww.com/jneuro-ophthalmology/Citation/9000/Visual_Disturbances_and_Headache_as_Presenting.98703.aspx

Worse Than the Disease? Reviewing Some Possible Unintended Consequences of the mRNA Vaccines Against COVID-19 | International Journal of Vaccine Theory, Practice, and Research

Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?
Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?
We describe a man whose first manifestations of Creutzfeldt-Jakob disease occurred in tand...